Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence.

Hannah J JonesGemma HammertonTayla McCloudLindsey A HinesCaroline WrightSuzanne H GagePeter HolmansPeter B JonesGeorge Davey SmithDavid E J LindenMichael C O'DonovanMichael J OwenJames T WaltersMarcus R MunafòJon HeronStanley Zammit

Published in: Psychological medicine (2020)

Our study provides evidence that genetic risk for schizophrenia is associated with patterns of cannabis use during adolescence. Investigation of pathways other than the cognitive, emotional, and behavioral phenotypes examined here is required to identify modifiable targets to reduce the public health burden of cannabis use in the population.

Keyphrases

public health
bipolar disorder
depressive symptoms
genome wide
copy number
risk factors
gene expression
dna methylation
global health