Helios expression and Foxp3 TSDR methylation of IFNy+ and IFNy- Treg from kidney transplant recipients with good long-term graft function.

Karina TrojanChristian UnterrainerRolf WeimerNuray BulutChristian MorathMostafa AlyLi ZhuGerhard OpelzVolker Daniel

Published in: PloS one (2017)

Kidney transplant recipients with good long-term stable graft function have similar levels of IFNy+ Treg as healthy controls. IFNy+ and IFNy- Treg subsets in patients consist of cells with stable and cells with transient Foxp3 expression; however, patients showed more frequently methylated IFNy+ and IFNy- Treg than controls. The data show increased levels of Treg subsets with stable as well as transient Foxp3 expression in patients with stable allograft acceptance compared to healthy controls.

Keyphrases

poor prognosis
end stage renal disease
regulatory t cells
induced apoptosis
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
cell cycle arrest
binding protein
gene expression
dna methylation
peripheral blood
brain injury
big data
endoplasmic reticulum stress
long non coding rna