The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis.
Kajetan KiełbowskiMariola HerianEstera BakinowskaBolesław BanachTomasz SroczyńskiAndrzej PawlikPublished in: International journal of molecular sciences (2023)
Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases, which take part in cartilage degradation. Furthermore, genetic factors also contribute to OA susceptibility. Recent studies have highlighted that epigenetic mechanisms may regulate the expression of OA-associated genes. This review aims to present the mechanisms of OA pathogenesis and summarise current evidence regarding the role of genetics and epigenetics in this process.
Keyphrases
- knee osteoarthritis
- poor prognosis
- genome wide
- rheumatoid arthritis
- type diabetes
- dna methylation
- oxidative stress
- metabolic syndrome
- multiple sclerosis
- weight loss
- insulin resistance
- binding protein
- extracellular matrix
- gene expression
- long non coding rna
- weight gain
- physical activity
- adipose tissue
- case control
- bone loss
- bioinformatics analysis
- bone regeneration