Physical exercise: a polypill against chronic kidney disease.
Pedro L ValenzuelaAdrián Castillo-GarcíaGonzalo Saco-LedoAlejandro Santos-LozanoAlejandro LuciaPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients' physical fitness and cardiovascular risk, as well as in kidney function). Exercise benefits are also found at advanced CKD stages or in patients under hemodialysis. The biological mechanisms behind the clinical evidence are also discussed. An active lifestyle appears as a cornerstone in CKD prevention and management.
Keyphrases
- chronic kidney disease
- end stage renal disease
- physical activity
- peritoneal dialysis
- ejection fraction
- newly diagnosed
- randomized controlled trial
- prognostic factors
- cardiovascular disease
- sars cov
- coronavirus disease
- type diabetes
- risk factors
- mental health
- depressive symptoms
- patient reported outcomes
- weight loss