WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape.

Chunwan LuZhuoqi LiuJohn D KlementDafeng YangAlyssa D MertingDakota PoschelThomas AlbersJennifer L WallerHuidong ShiZhuoqi Liu

Published in: Journal for immunotherapy of cancer (2022)

OPN compensates PD-L1 function to promote pancreatic cancer immune escape. Pharmacological inhibition of the WDR5-H3K4me3 epigenetic axis is effective in suppressing pancreatic tumor immune escape and in improving efficacy of anti-PD-1 immunotherapy in pancreatic cancer.

Keyphrases

dna methylation
gene expression
poor prognosis
signaling pathway
binding protein
long non coding rna