Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs.
Yifang YangJunshu WuDefu WuQi WeiTan ZhongJun YangXiaowei YangMeizhen ZengXingwu ZhongPublished in: Eye and vision (London, England) (2021)
Among the 3 different administration methods, intravitreal injection of brimonidine was the most effective in slowing myopia progression in the FD guinea pig model. Intravitreal brimonidine at 4 μg/μL significantly reduced the development of FD myopia in guinea pigs. Expression levels of the Col1a1 and Mmp2 genes were significantly increased in the retinal tissues of the FD-Inj-Br group.