Genome-Wide Occupancy Profiling Reveals Critical Roles of FoxO1 in Regulating Extracellular Matrix and Circadian Rhythm Genes in Human Chondrocytes.

Tomás Duffy Hirofumi Bekki Martin K Lotz

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

FoxO1 regulates ubiquitous and cartilage-specific genes in chondrocytes by using different mechanisms. The FoxO1 transcriptional network is a key player in regulating homeostasis, ECM, and circadian clock genes and plays an important role in the abnormal expression of these pathways observed in OA pathogenesis.

Keyphrases

extracellular matrix
genome wide
transcription factor
genome wide identification
dna methylation
signaling pathway
pi k akt
bioinformatics analysis
endothelial cells
poor prognosis
gene expression
blood pressure
oxidative stress
genome wide analysis
heat shock protein