Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis.
Tamara Šljivančanin JakovljevićJelena MarticJelena JacimovicNadja NikolicJelena MilasinTanja Lazić MitrovićPublished in: World journal of pediatrics : WJP (2022)
Out of the 11 investigated single-nucleotide polymorphisms, this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 polymorphisms. There is an evident need for larger well-designed, multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.