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Association between innate immunity gene polymorphisms and neonatal sepsis development: a systematic review and meta-analysis.

Tamara Šljivančanin JakovljevićJelena MarticJelena JacimovicNadja NikolicJelena MilasinTanja Lazić Mitrović
Published in: World journal of pediatrics : WJP (2022)
Out of the 11 investigated single-nucleotide polymorphisms, this meta-analysis found a possible association between the risk for culture-proven sepsis and MBL exon 1 and TLR4 rs4986791 polymorphisms. There is an evident need for larger well-designed, multicentric observational studies investigating inflammatory gene polymorphisms in neonatal sepsis.
Keyphrases
  • septic shock
  • acute kidney injury
  • intensive care unit
  • systematic review
  • toll like receptor
  • inflammatory response
  • oxidative stress
  • immune response
  • randomized controlled trial
  • high resolution