Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging.

Sang Gyun NohHee Jin JungSeungwoo KimRadha ArulkumarDae Hyun KimDaeui Park Hae Young Chung

Published in: International journal of molecular sciences (2022)

Age-related elevation of Nr1d1/2 downregulates the expression of other circadian genes in males, but not females, during liver aging. Consequently, age-related upregulation of Nr1d1/2 may play a more crucial role in the change in circadian rhythms in males than in females during liver aging.

Keyphrases

poor prognosis
genome wide
cell proliferation
bioinformatics analysis
gene expression
binding protein