Unique Metabolomic and Lipidomic Profile in Serum From Patients With Crohn's Disease and Ulcerative Colitis Compared With Healthy Control Individuals.
Hauke Christian TewsFranziska SchmelterArne KandulskiChrista BüchlerStephan SchmidSophie SchlosserTanja ElgerJohanna LoiblStefanie SommersbergerTanja FererbergerStefan GunawanClaudia KunstKarsten GülowDominik BettenworthBandik FöhCarlos MaaßPhilipp SolbachUlrich L GüntherStefanie DererJens U MarquardtChristian SinaMartina MüllerPublished in: Inflammatory bowel diseases (2023)
Metabolomic assessment of serum samples facilitated the differentiation of IBD patients and HC individuals. These differences were constituted by changes in amino acid and lipoprotein levels. Furthermore, disease activity in IBD patients was associated with decreased levels of the atheroprotective apolipoproteins A1 and A2.