Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway.
Szu-Yuan WuYan-Jiun HuangYew-Min TzengChi-Ying F HuangMichael HsiaoAlexander Tsang-Hsien WuTse-Hung HuangPublished in: Cancers (2018)
We provided evidence of DB as a potential therapeutic agent for overcoming 5-FU resistance induced by IGF1, and suppressing cancer stem-like properties in association with miR-214 regulation. Further investigation is warranted for its translation to clinical application.
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