Effectiveness and Safety of Direct-Acting Antiviral Combination Therapies for Treatment of Hepatitis C Virus in Elderly Patients: Results from the German Hepatitis C Registry.

Georg DultzTobias MüllerJörg PetersenStefan MaussTim ZimmermannMarion MucheKarl-Georg SimonThomas BergStefan ZeuzemDietrich HüppeKlaus BökerHeiner WedemeyerTania M Welzelnull null

Published in: Drugs & aging (2018)

Direct-acting antiviral therapies were well tolerated in patients older than 70 years. SVR12 rates in the elderly patient group were similar to those observed in younger patients. Differences in the prevalence of comorbidities between age groups warrant individualized attention with respect to drug-drug interactions and therapy adherence. The study was registered in the German Clinical Trials Register, DRKS-ID: DRKS00009717.

Keyphrases

end stage renal disease
clinical trial
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
randomized controlled trial
adipose tissue
type diabetes
metabolic syndrome
middle aged
human immunodeficiency virus
working memory
skeletal muscle
patient reported
replacement therapy
drug induced