MTT and Blood-Brain Barrier Disruption within Asymptomatic Vascular WM Lesions.
Blake E DeweyXiang XuLinda KnutssonA JogJerry L PrincePeter B BarkerPeter C M van ZijlRichard LeighPaul A NyquistPublished in: AJNR. American journal of neuroradiology (2021)
A dual-contrast-injection MR imaging protocol combined with a 3D automated segmentation analysis pipeline was used to assess BBB disruption in white matter lesions on the basis of quantitative perfusion measures including the volume transfer constant (dynamic contrast-enhanced imaging), the BBB leakage parameter (DSC), and MTT (DSC). This protocol was able to detect early pathologic changes in otherwise healthy individuals.
Keyphrases
- blood brain barrier
- white matter
- contrast enhanced
- deep learning
- high resolution
- randomized controlled trial
- cerebral ischemia
- magnetic resonance imaging
- machine learning
- convolutional neural network
- multiple sclerosis
- high throughput
- computed tomography
- radiation therapy
- ultrasound guided
- lymph node
- subarachnoid hemorrhage