Protease-activated receptor-2 suppresses interleukin (IL)-10 expression in B cells via upregulating Bcl2L12 in patients with allergic rhinitis.

J-M XueL-T YangG YangX-R GengZhi-Qiang LiuS WangH-L ZhaoZ-G LiuC-Q ZhaoP-C Yang

Published in: Allergy (2017)

Activation of PAR2 inhibits the expression of IL-10 in B cells, which can be reversed by treating B cells with Bcl2L12 shRNA-carrying liposomes. The data suggest that regulation of Bcl2L12 may be a novel approach in the treatment for AR.

Keyphrases

allergic rhinitis
poor prognosis
binding protein
signaling pathway
big data
deep learning
data analysis