The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial.
Rosalind FallaizeCarlos A Celis-MoralesAnna L MacreadyCyril F M MarsauxHannah ForsterClare O'DonovanClara WoolheadRodrigo San-CristobalSilvia KolossaJacqueline HallmannChristina MavrogianniAgnieszka SurwilloKatherine M LivingstoneGeorge MoschonisSantiago Navas-CarreteroMarianne C WalshEileen R GibneyLorraine BrennanJildau BouwmanKeith GrimaldiYannis ManiosIwona TraczykChristian A DrevonJ Alfredo MartinezHannelore DanielWim Hm SarisMichael J GibneyJohn Cummings MathersJulie Anne Lovegrovenull nullPublished in: The American journal of clinical nutrition (2016)
The APOE ɛ4 allele was associated with higher TC. Although gene-based PN targeted to APOE was more effective in reducing SFA intake than standard dietary advice, there was no difference between APOE "risk" and "nonrisk" groups. Furthermore, disclosure of APOE nonrisk may have weakened dietary response to PN. This trial was registered at clinicaltrials.gov as NCT01530139.