In this narrative review, we present a comprehensive assessment on the putative roles of long non-coding RNAs (lncRNAs) in intermittent hypoxia (IH) and sleep apnea. Collectively, the evidence from cell culture, animal, and clinical research studies points to the functional involvement of lncRNAs in the pathogenesis, diagnosis, and potential treatment strategies for this highly prevalent disorder. Further research is clearly warranted to uncover the mechanistic pathways and to exploit the therapeutic potential of lncRNAs, thereby improving the management and outcomes of patients suffering from sleep apnea.
Keyphrases
- sleep apnea
- positive airway pressure
- long non coding rna
- obstructive sleep apnea
- network analysis
- genome wide analysis
- end stage renal disease
- genome wide identification
- ejection fraction
- endothelial cells
- newly diagnosed
- poor prognosis
- high intensity
- prognostic factors
- type diabetes
- adipose tissue
- patient reported outcomes
- skeletal muscle
- human health
- insulin resistance