IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development.

Lei LvQinqin WeiJianxiao ZhangYitong DongZhenglei ShanNa ChangYe ZhaoPo BianQiyi Yi

Published in: Cellular & molecular biology letters (2024)

Our present study sheds light on the genetic and epigenetic mechanisms governing IGF2BP3 expression, underscoring the critical involvement of the IGF2BP3-HMGB1 axis in driving bladder cancer progression. Additionally, it advocates for the investigation of inhibiting IGF2BP3-HMGB1 as a viable therapeutic approach for treating bladder cancer.

Keyphrases

binding protein
pi k akt
growth hormone
signaling pathway
poor prognosis
dna methylation
gene expression
long non coding rna
muscle invasive bladder cancer