A pH probe inhibits senescence in mesenchymal stem cells.

Lihong WangXianjing HanGuojing QuLe SuBaoxiang ZhaoJun-Ying Miao

Published in: Stem cell research & therapy (2018)

Our work showed that SGJ could inhibit senescence in BMSCs and protect lysosomes by promoting expression of LAMP1 and LAMP2. Meanwhile, SGJ could promote autophagy. Furthermore, our study also suggested that SGJ was a new Baf-A1 antagonist because SGJ could target and occupy the V0 proton channel of v-ATPase.

Keyphrases

mesenchymal stem cells
dna damage
loop mediated isothermal amplification
endothelial cells
poor prognosis
cell death
stress induced
umbilical cord
endoplasmic reticulum stress
bone marrow
binding protein
long non coding rna
sensitive detection