Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma.
Marcus A WeinmanStephen A RamseyHaley J LeeperJacqueline V BradyAndrew SchlueterStanislau StanisheuskiClaudia S MaierTasha MillerCarl E RubyShay BrachaPublished in: Cancer cell international (2021)
The findings of this study highlight the significance of exosomes in the potential transfer of drug resistance, and the discovery of novel biomarkers for the development of liquid biopsies to better guide personalized chemotherapy treatment.
Keyphrases
- mesenchymal stem cells
- small molecule
- stem cells
- high throughput
- phase ii study
- locally advanced
- genome wide
- randomized controlled trial
- ultrasound guided
- ionic liquid
- squamous cell carcinoma
- dna methylation
- risk assessment
- label free
- radiation therapy
- climate change
- open label
- study protocol
- chemotherapy induced
- phase iii