We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined multigene signature including APOD, DCN, and LUM. This cell population has previously been labeled as consisting of inflammatory cancer-associated fibroblasts (iCAFs). The same signature characterizes naturally occurring fibro-adipogenic progenitors (FAPs) as well as stromal cells abundant in normal adipose tissue. Our analysis of human gene expression databases provides evidence that adipose stromal cells (ASCs) are recruited by tumors and undergo differentiation into CAFs during cancer progression to invasive and chemotherapy-resistant stages.
Keyphrases
- adipose tissue
- gene expression
- single cell
- cell therapy
- insulin resistance
- high grade
- endothelial cells
- dna methylation
- type diabetes
- oxidative stress
- stem cells
- photodynamic therapy
- papillary thyroid
- high fat diet
- squamous cell carcinoma
- big data
- skeletal muscle
- computed tomography
- young adults
- pet imaging
- mesenchymal stem cells
- metabolic syndrome
- deep learning
- extracellular matrix
- combination therapy
- pluripotent stem cells
- childhood cancer