Effect of Sleep Disturbance on Efficacy of Esketamine in Treatment-Resistant Depression: Findings from Randomized Controlled Trials.

Stephane BorentainDavid WilliamsonIbrahim TurkozVanina PopovaWilliam V McCallMaju MathewsFrank Wiegand

Published in: Neuropsychiatric disease and treatment (2021)

Antidepressant efficacy of esketamine was demonstrated in patients with TRD, regardless of the presence of sleep disturbance. After 8 days of treatment and thereafter, significantly more esketamine-treated patients reported improvement in sleep versus antidepressant plus placebo.

Keyphrases

sleep quality
end stage renal disease
physical activity
major depressive disorder
newly diagnosed
randomized controlled trial
ejection fraction
chronic kidney disease
depressive symptoms
peritoneal dialysis
clinical trial
patient reported outcomes
double blind
patient reported