Maternal age at delivery, lung function and asthma in offspring: a population-based survey.
Francisco Gómez RealJohn A BurgessSimona VillaniJulia DratvaJoachim HeinrichChrister JansonDebbie JarvisJennifer KoplinBénédicte LeynaertCaroline LodgeBirger N LærumMelanie C MathesonDan NorbäckErnst R OmenaasSvein M SkulstadJordi SunyerShyamali C DharmageCecilie SvanesPublished in: The European respiratory journal (2018)
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry.Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (ptrend 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (pinteraction 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors.Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- cystic fibrosis
- pregnancy outcomes
- air pollution
- birth weight
- healthcare
- gestational age
- high fat diet
- pregnant women
- physical activity
- type diabetes
- body mass index
- mental health
- risk assessment
- sleep quality
- metabolic syndrome
- insulin resistance
- public health
- smoking cessation
- deep learning
- artificial intelligence
- respiratory tract
- mechanical ventilation
- cross sectional
- adipose tissue
- young adults
- extracorporeal membrane oxygenation