Pharmacokinetic-based failure of a detergent virucidal for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) nasal infections: A preclinical study and randomized controlled trial.
Charles R EstherKyle S KimuraYu MikamiCaitlin E EdwardsSuman R DasMichael H FreemanBritton A StricklandHunter M BrownBronson C WessingerVeerain C GuptaKate Von WahldeQuanhu ShengLi Ching HuangDaniel R BaconAdam J KimpleAgathe S CeppeTakafumi KatoRaymond J PicklesScott H RandellRalph S BaricJustin H TurnerRichard C BoucherPublished in: International forum of allergy & rhinology (2022)
In this randomized clinical trial of subjects with SARS-CoV-2 infection, a topical detergent-based virucidal agent had no effect on viral load or symptom scores. Complementary in vitro studies confirmed a lack of efficacy, reflective of pharmacokinetic failure and rapid absorption from nasal surfaces.