Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye.
Amy N RiesenbergKevin W ConleyTien T LeNadean L BrownPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)
Hes5-GFP BAC transgenic mice are useful for identifying Hes5-expressing cells. Although Hes5-GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5-GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis-regulatory elements that regulate endogenous Hes5 in the mouse lens and retina. Developmental Dynamics 247:212-221, 2018. © 2017 Wiley Periodicals, Inc.