Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome-Wide Association Study and Inverse Variance-Weighted Meta-Analysis.

Vivian K KawaiMingjian ShiQiping FengCecilia P ChungGe LiuNancy J CoxGail P JarvikMing T M LeeScott J HebbringJohn B HarleyKenneth M KaufmanBahram NamjouEric LarsonAdam S GordonDan M RodenC Michael SteinJonathan D Mosleynull null

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

This study presents evidence of pleiotropy between the genetic predisposition to RA and associated phenotypes found in other autoimmune and cardiometabolic disorders, including type 1 DM.

Keyphrases

rheumatoid arthritis
systematic review
genome wide
disease activity
type diabetes
multiple sclerosis
randomized controlled trial
magnetic resonance imaging
adipose tissue
systemic lupus erythematosus
interstitial lung disease
copy number
ankylosing spondylitis
drug induced