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Hyperfols A and B: Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum perforatum.

Hua-Yong LouYa-Nan LiPing YiJun-You JianZhan-Xing HuWei GuLie-Jun HuangYan-Mei LiChun-Mao YuanXiao-Jiang Hao
Published in: Organic letters (2020)
Two novel polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperfols A (1) and B (2), and two known biosynthetically related precursors (3 and 4) were isolated from Hypericum perforatum. Compound 1 possesses an unprecedented 2,3-seco-PPAP with a fused 5/5/9/5 tetracyclic skeleton, and 2 features a 30-norPPAP. Their structures were established by spectroscopic analysis, computer-assisted structure elucidation software, and electronic circular dichroism calculations. Moreover, compounds 1 and 4 exhibit significant cytotoxicity against human erythroleukemia cells by inducing cell apoptosis.
Keyphrases
  • induced apoptosis
  • endothelial cells
  • cell cycle arrest
  • molecular docking
  • cell proliferation
  • density functional theory
  • high resolution
  • induced pluripotent stem cells
  • pluripotent stem cells
  • monte carlo