TP53 codon 72 polymorphism is associated with FGFR3 and RAS mutation in non-muscle-invasive bladder cancer.

Takashi KawaharaTakahiro KojimaShuya KandoriMasahiro KurobeTakayuki YoshinoTomokazu KimuraYoshiyuki NagumoRyutaro IshitukaKoji MitsuzukaShintaro NaritaTakashi KobayashiYoshiyuki MatsuiOsamu OgawaMikio SugimotoJun MiyazakiHiroyuki Nishiyama

Published in: PloS one (2019)

The germline TP53 codon 72 polymorphism was associated with mutations of FGFR3 or RAS and expression of FGFR1 and FGFR3 in NMIBC. These findings provide new insight into the molecular mechanisms underlying the influence of the genetic background on carcinogenesis in bladder cancer.

Keyphrases

muscle invasive bladder cancer
poor prognosis
wild type
dna repair
gene expression
single molecule
copy number
oxidative stress
dna damage