Antiinflammatory Effect of High-Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis.

Qiong WuQuanhu ShengDanielle MichellMarisol Ramirez-SolanoOlivia PoseyAnastasiia PhothisaneShahensha ShaikKasey C VickersMichelle J Ormseth

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

HDL-miR-1246 was increased in RA versus control participants and delivery of miR-1246 to macrophages increased IL-6 expression by targeting DUSP3. The altered HDL-miRNA cargo in RA blunted HDL's anti-inflammatory effect.

Keyphrases

high density
long non coding rna
cell proliferation
poor prognosis
rheumatoid arthritis
long noncoding rna
anti inflammatory
disease activity
ankylosing spondylitis
binding protein
interstitial lung disease