Single nucleotide editing without DNA cleavage using CRISPR/Cas9-deaminase in the sea urchin embryo.

Saba ShevidiAlicia UchidaNatalie SchudrowitzGary M WesselMamiko Yajima

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)

These results suggest that the Cas9-DA approach may be useful for manipulating gene activity with decreased risks of genomic aberrations. Developmental Dynamics 246:1036-1046, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

crispr cas
copy number
genome editing
genome wide
circulating tumor
cell free
human health
single molecule
dna methylation
dna binding
genome wide identification
gene expression
transcription factor
climate change
circulating tumor cells
genome wide analysis