High prevalence of "non-pathogenic" POLE mutation with poor prognosis in a cohort of endometrial cancer from South India.

Santhosh Kuriakose Dhananjayan DhanasoorajP M ShinyS ShammyV P SonaAnupama A ManjulaAmrutha RamachandranBindu VijaykumarNayana SusanM DinesanUma V SankarKavitha RamachandranP S Sreedharan

Published in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2024)

This study identified a unique set of POLE mutations in Indian EC patients associated with poor prognosis, which were particularly pronounced in advanced stages. Advanced stage of presentation, type of POLE mutations, and possibly ethnicity are predictors of adverse outcomes in POLE-mutated EC. The present study highlights ethnicity as a determinant of phenotypic expression of genetic change.

Keyphrases

poor prognosis
long non coding rna
endometrial cancer
end stage renal disease
ejection fraction
newly diagnosed
gene expression
prognostic factors
dna methylation
copy number
patient reported outcomes