Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.

Rathana Kim Hugo Bergugnat Lise Larcher Matthieu Duchmann Marie Passet Stéphanie Gachet Wendy Cuccuini Marina Lafage-Pochitaloff Cédric Pastoret Nathalie Grardel Vahid Asnafi Beat W Schäfer Eric Delabesse Raphaël A Itzykson Lionel Ades Yosr Hicheri Yves Chalandon Carlos Graux Patrice Chevallier Mathilde M Hunault-Berger Thibaut Tl Leguay Françoise Huguet Véronique Lhéritier Hervé Dombret Jean Soulier Philippe Rousselot Nicolas Boissel Emmanuelle Clappier

Published in: Blood cancer discovery (2023)

We show that low-hypodiploid ALL is a frequent entity within B-ALL in older adults, relying on somatic TP53 biallelic alteration. Our study unveils a link between aging and low-hypodiploid ALL, with TP53-mutant clonal hematopoiesis representing a preleukemic reservoir that can give rise to aneuploidy and B-ALL. See related commentary by Saiki and Ogawa, p. 102. This article is highlighted in the In This Issue feature, p. 101.

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