Evaluation of Priming Efficiency of Forskolin in Tissue-Specific Human Mesenchymal Stem Cells into Dopaminergic Neurons: An In Vitro Comparative Study.
Manisha SinghPardeep Kumar VaishnavAmit Kumar DindaSujata MohantyPublished in: Cells (2020)
It may be concluded that a combination of FGF2 and forskolin yields functionally active dopaminergic neuronal cells in vitro, with highest percentage of the same from AD-MSCs, as compared to that in BM-MSCs and DP-MSCs. The outcomes and comparative evaluation provide a substantial platform for further studies on molecular pathways involved in the process of DAergic neurogenesis in individual cases.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- induced apoptosis
- bone marrow
- endothelial cells
- cell therapy
- cell cycle arrest
- cerebral ischemia
- spinal cord
- high throughput
- induced pluripotent stem cells
- endoplasmic reticulum stress
- oxidative stress
- cell death
- pluripotent stem cells
- spinal cord injury
- insulin resistance
- neural stem cells