Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis.
Zheqi LiYang WuMegan E YatesNilgun TasdemirAmir BahreiniJian ChenKevin M LevineNolan M PriedigkeitAzadeh NasrazadaniSimak AliLaki BuluwelaSpencer ArnesenJason GertzJennifer K RicherBenjamin TronessDorraya El-AshryQiang ZhangLorenzo GerratanaYoubin ZhangMassimo CristofanilliMaritza A MontanezPrithu SunddCallen T WallaceSimon C WatkinsCaterina FumagalliElena Guerini RoccoLi ZhuGeorge C TsengNikhil WagleJason S CarrollPaul JankCarsten DenkertMaria M KarstenJens-Uwe BlohmerBen H ParkPeter C LucasJennifer M AtkinsonAdrian V LeeSteffi OesterreichPublished in: Cancer research (2022)
Context- and allele-dependent transcriptome and cistrome reprogramming in mutant ESR1 cell models elicit diverse metastatic phenotypes related to cell adhesion and migration, which can be pharmacologically targeted in metastatic breast cancer.