Simak Ali (S Ali)

Loop profile ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 42

Top Venues

Nature communications

JCO precision oncology

Oncogene

Cancers

University of Edinburgh (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of Edinburgh Oct 01 1985 - Sep 30 1988

United Kingdom

PHD :: Genetics

Imperial College London Sep 15 1982 - Jul 23 1985

United Kingdom

BSC

Publications

Julia N Cheng, Jennifer B Frye, Susan A Whitman, Sima Ehsani, Simak Ali, Janet L Funk
Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice. Endocrinology 165 (6) (2024)
Julia N Cheng, Jennifer B Frye, Susan A Whitman, Sima Ehsani, Simak Ali, Janet L Funk
Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice. Endocrinology 165 (6) (2024)
Julia N Cheng, Jennifer B Frye, Susan A Whitman, Sima Ehsani, Simak Ali, Janet L Funk
Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice. Endocrinology 165 (6) (2024)
Nicola J Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Mark Edmond, Benjamin P Sharpe, Damian Amendra, Ke Zheng, Nagayasu Egawa, John Doorbar, Anjali Rao, Sangeetha Mahadevan, Michael A Carpenter, Reuben Stewart Harris, Simak Ali, Christopher J Hanley, Rémi Buisson, Emma King, Gareth J Thomas, Tim R Fenton
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. Research square (2024)
Victoria I Cushing, Adrian Fujiet Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H B Kroll, Marion Barbazanges, Bodo Scheiper, Ash K Bahl, Anthony G M Barrett, Simak Ali, Abhay Kotecha, Basil J Greber
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nature communications 15 (1) (2024)
Victoria I Cushing, Adrian Fujiet Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H B Kroll, Marion Barbazanges, Bodo Scheiper, Ash K Bahl, Anthony G M Barrett, Simak Ali, Abhay Kotecha, Basil J Greber
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nature communications 15 (1) (2024)
Jacqueline A Shaw, Karen Page, Evie Wren, Elza C de Bruin, Ekaterina Kalashnikova, Robert Hastings, Rob McEwen, Eddie Zhang, Marc Wadsley, Emmanuel Acheampong, Derrick Renner, Kelly L T Gleason, Bana Ambasager, Daniel Stetson, Daniel Fernandez-Garcia, David Guttery, Rebecca C Allsopp, Angel Rodriguez, Bernhard Zimmermann, Himanshu Sethi, Alexey Aleshin, Minetta C Liu, Cathy J Richards, Justin Stebbing, Simak Ali, Farah Rehman, Susan Cleator, Laura Kenny, Samreen Ahmed, Anne C Armstrong, Raoul Charles Coombes
Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer. JCO precision oncology 8 (2024)
Jacqueline A Shaw, Karen Page, Evie Wren, Elza C de Bruin, Ekaterina Kalashnikova, Robert Hastings, Rob McEwen, Eddie Zhang, Marc Wadsley, Emmanuel Acheampong, Derrick Renner, Kelly L T Gleason, Bana Ambasager, Daniel Stetson, Daniel Fernandez-Garcia, David Guttery, Rebecca C Allsopp, Angel Rodriguez, Bernhard Zimmermann, Himanshu Sethi, Alexey Aleshin, Minetta C Liu, Cathy J Richards, Justin Stebbing, Simak Ali, Farah Rehman, Susan Cleator, Laura Kenny, Samreen Ahmed, Anne C Armstrong, Raoul Charles Coombes
Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer. JCO precision oncology 8 (2024)
Nicola Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Rémi Buisson, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Benjamin P Sharpe, Damian Amendra, Christopher J Hanley, Emma King, Gareth J Thomas, Mark Edmond, Simak Ali, Ke Zheng, Nagayasau Egawa, John Doorbar, Michael Carpenter, Reuben Stewart Harris, Anjali Rao, Sangeetha Mahadevan, Tim R Fenton
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. Research square (2024)
Talvinder Bhogal, Athina Giannoudis, Ethan S Sokol, Simak Ali, Carlo Palmieri
Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease. JCO precision oncology 8 (2024)
Talvinder Bhogal, Athina Giannoudis, Ethan S Sokol, Simak Ali, Carlo Palmieri
Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease. JCO precision oncology 8 (2024)
Julia N Cheng, Jennifer B Frye, Susan A Whitman, Sima Ehsani, Simak Ali, Janet L Funk
Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice. Endocrinology 165 (6) (2024)
Victoria I Cushing, Adrian Fujiet Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H B Kroll, Marion Barbazanges, Bodo Scheiper, Ash K Bahl, Anthony G M Barrett, Simak Ali, Abhay Kotecha, Basil J Greber
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nature communications 15 (1) (2024)
Jacqueline A Shaw, Karen Page, Evie Wren, Elza C de Bruin, Ekaterina Kalashnikova, Robert Hastings, Rob McEwen, Eddie Zhang, Marc Wadsley, Emmanuel Acheampong, Derrick Renner, Kelly L T Gleason, Bana Ambasager, Daniel Stetson, Daniel Fernandez-Garcia, David Guttery, Rebecca C Allsopp, Angel Rodriguez, Bernhard Zimmermann, Himanshu Sethi, Alexey Aleshin, Minetta C Liu, Cathy J Richards, Justin Stebbing, Simak Ali, Farah Rehman, Susan Cleator, Laura Kenny, Samreen Ahmed, Anne C Armstrong, Raoul Charles Coombes
Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer. JCO precision oncology 8 (2024)
Victoria I Cushing, Adrian Fujiet Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H B Kroll, Marion Barbazanges, Bodo Scheiper, Ash K Bahl, Anthony G M Barrett, Simak Ali, Abhay Kotecha, Basil J Greber
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nature communications 15 (1) (2024)
Jacqueline A Shaw, Karen Page, Evie Wren, Elza C de Bruin, Ekaterina Kalashnikova, Robert Hastings, Rob McEwen, Eddie Zhang, Marc Wadsley, Emmanuel Acheampong, Derrick Renner, Kelly L T Gleason, Bana Ambasager, Daniel Stetson, Daniel Fernandez-Garcia, David Guttery, Rebecca C Allsopp, Angel Rodriguez, Bernhard Zimmermann, Himanshu Sethi, Alexey Aleshin, Minetta C Liu, Cathy J Richards, Justin Stebbing, Simak Ali, Farah Rehman, Susan Cleator, Laura Kenny, Samreen Ahmed, Anne C Armstrong, Raoul Charles Coombes
Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer. JCO precision oncology 8 (2024)
Nicola Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Rémi Buisson, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Benjamin P Sharpe, Damian Amendra, Christopher J Hanley, Emma King, Gareth J Thomas, Mark Edmond, Simak Ali, Ke Zheng, Nagayasau Egawa, John Doorbar, Michael Carpenter, Reuben Stewart Harris, Anjali Rao, Sangeetha Mahadevan, Tim R Fenton
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. Research square (2024)
Theodora A Constantin, Anabel Varela-Carver, Kyle K Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A Leach, Chun-Fui Lai, Edward K Ainscow, Ash K Bahl, David Carling, Matthew John Fuchter, Simak Ali, Charlotte Lynne Bevan
Correction: The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer. British journal of cancer (2024)
Raoul Charles Coombes, Sacha Howell, Simon R Lord, Laura Kenny, Janine Mansi, Zahi I Mitri, Carlo Palmieri, Linnea I Chap, Paul Richards, William J Gradishar, Sagar Sardesai, Jason Melear, Joyce O'Shaughnessy, Patrick J Ward, Pavani Chalasani, Tobias Arkenau, Richard D Baird, Rinath M Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G Krebs
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib. Nature communications 14 (1) (2023)
Lubaid Saleh, Penelope D Ottewell, Janet E Brown, Steven L Wood, Nichola J Brown, Caroline Wilson, Catherine Park, Simak Ali, Ingunn Holen
The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo. Cancers 15 (8) (2023)
Raoul Charles Coombes, Sacha Howell, Simon R Lord, Laura Kenny, Janine Mansi, Zahi I Mitri, Carlo Palmieri, Linnea I Chap, Paul Richards, William J Gradishar, Sagar Sardesai, Jason Melear, Joyce O'Shaughnessy, Patrick J Ward, Pavani Chalasani, Tobias Arkenau, Richard D Baird, Rinath M Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G Krebs
Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib. Nature communications 14 (1) (2023)
Lubaid Saleh, Penelope D Ottewell, Janet E Brown, Steven L Wood, Nichola J Brown, Caroline Wilson, Catherine Park, Simak Ali, Ingunn Holen
The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo. Cancers 15 (8) (2023)
Ebtihal H Mustafa, Geraldine Laven-Law, Zoya Kikhtyak, Van Nguyen, Simak Ali, Alex A Pace, Richard Iggo, Alemwork Kebede, Ben Noll, Shudong Wang, Jean M Winter, Amy R Dwyer, Wayne D Tilley, Theresa E Hickey
Selective inhibition of CDK9 in triple negative breast cancer. Oncogene (2023)
George Alexandrou, Katerina-Theresa Mantikas, Rebecca Allsopp, Calista Adele Yapeter, Myesha Jahin, Taryn Melnick, Simak Ali, R Charles Coombes, Christofer Toumazou, Jacqueline A Shaw, Melpomeni Kalofonou
The Evolution of Affordable Technologies in Liquid Biopsy Diagnostics: The Key to Clinical Implementation. Cancers 15 (22) (2023)
Theodora A Constantin, Anabel Varela-Carver, Kyle K Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A Leach, Chun-Fui Lai, Edward K Ainscow, Ash K Bahl, David Carling, Matthew John Fuchter, Simak Ali, Charlotte Lynne Bevan
The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer. British journal of cancer (2023)
Patrick Aouad, Yueyun Zhang, Fabio De Martino, Céline Stibolt, Simak Ali, Giovanna Ambrosini, Sendurai A Mani, Kelly Maggs, Hazel M Quinn, George Sflomos, Cathrin Brisken
Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nature communications 13 (1) (2022)
Zheqi Li, Olivia McGinn, Yang Wu, Amir Bahreini, Nolan M Priedigkeit, Kai Ding, Sayali Onkar, Caleb Lampenfeld, Carol A Sartorius, Lori Miller, Margaret Rosenzweig, Ofir Cohen, Nikhil Wagle, Jennifer K Richer, William J Muller, Lakjaya Buluwela, Simak Ali, Tullia C Bruno, Dario A A Vignali, Yusi Fang, Li Zhu, George C Tseng, Jason Gertz, Jennifer M Atkinson, Adrian V Lee, Steffi Oesterreich
ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation. Nature communications 13 (1) (2022)
Alison Harrod, Chun-Fui Lai, Isabella Goldsbrough, Georgia M Simmons, Natasha Oppermans, Daniela B Santos, Balazs Győrffy, Rebecca C Allsopp, Bradley J Toghill, Kirsty Balachandran, Mandy Lawson, Christopher J Morrow, Manasa Surakala, Larissa S Carnevalli, Pei Zhang, David S Guttery, Jacqueline A Shaw, Raoul Charles Coombes, Lakjaya Buluwela, Simak Ali
Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer. Oncogene 41 (44) (2022)
Zheqi Li, Yang Wu, Megan E Yates, Nilgun Tasdemir, Amir Bahreini, Jian Chen, Kevin M Levine, Nolan M Priedigkeit, Azadeh Nasrazadani, Simak Ali, Laki Buluwela, Spencer Arnesen, Jason Gertz, Jennifer K Richer, Benjamin Troness, Dorraya El-Ashry, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Massimo Cristofanilli, Maritza A Montanez, Prithu Sundd, Callen T Wallace, Simon C Watkins, Caterina Fumagalli, Elena Guerini Rocco, Li Zhu, George C Tseng, Nikhil Wagle, Jason S Carroll, Paul Jank, Carsten Denkert, Maria M Karsten, Jens-Uwe Blohmer, Ben H Park, Peter C Lucas, Jennifer M Atkinson, Adrian V Lee, Steffi Oesterreich
Hotspot ESR1 Mutations Are Multimodal and Contextual Modulators of Breast Cancer Metastasis. Cancer research 82 (7) (2022)
Simon C Baker, Andrew S Mason, Raphael G Slip, Katie T Skinner, Andrew Macdonald, Omar Masood, Reuben Stewart Harris, Tim R Fenton, Manikandan Periyasamy, Simak Ali, Jennifer Southgate
Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer. Oncogene 41 (15) (2022)
Daniel Fernandez-Garcia, Georgios Nteliopoulos, Robert K Hastings, Amelia Rushton, Karen Page, Rebecca C Allsopp, Bana Ambasager, Kelly Gleason, David S Guttery, Simak Ali, Raoul Charles Coombes, Jacqueline A Shaw
Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer. British journal of cancer 127 (10) (2022)
Isabel Mayayo-Peralta, Beatrice Faggion, Liesbeth Hoekman, Ben Morris, Cor Lieftink, Isabella Goldsbrough, Lakjaya Buluwela, Joseph C Siefert, Harm Post, Maarten Altelaar, Roderick Beijersbergen, Simak Ali, Wilbert Zwart, Stefan Prekovic
Ribociclib Induces Broad Chemotherapy Resistance and EGFR Dependency in ESR1 Wildtype and Mutant Breast Cancer. Cancers 13 (24) (2021)
Melpomeni Kalofonou, Kenny Malpartida-Cardenas, George Alexandrou, Jesus Rodriguez-Manzano, Ling-Shan Yu, Nicholas Miscourides, Rebecca Allsopp, Kelly L T Gleason, Katie Goddard, Daniel Fernandez-Garcia, Karen Page, Pantelis Georgiou, Simak Ali, R Charles Coombes, Jacqueline A Shaw, Christofer Toumazou
A novel hotspot specific isothermal amplification method for detection of the common PIK3CA p.H1047R breast cancer mutation. Scientific reports 10 (1) (2020)
Manikandan Periyasamy, Anup K Singh, Carolina Gemma, Raed Farzan, Rebecca C Allsopp, Jacqueline A Shaw, Sara Charmsaz, Leonie S Young, Paula Cunnea, R Charles Coombes, Balázs Győrffy, Lakjaya Buluwela, Simak Ali
Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB. Oncogene 40 (6) (2020)
Hajnalka L Pálinkás, Angéla Békési, Gergely Róna, Lőrinc Pongor, Gábor Papp, Gergely Tihanyi, Eszter Holub, Ádám Póti, Carolina Gemma, Simak Ali, Michael J Morten, Eli Rothenberg, Michele Pagano, Dávid Szűts, Balázs Győrffy, Beáta G Vértessy
Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments. eLife 9 (2020)
Koen D Flach, Manikandan Periyasamy, Ajit Jadhav, Dorjbal Dorjsuren, Joseph C Siefert, Theresa E Hickey, Mark Opdam, Hetal Patel, Sander Canisius, David M Wilson, Maria Donaldson Collier, Stefan Prekovic, Marja Nieuwland, Roelof J C Kluin, Alexey V Zakharov, Jelle Wesseling, Lodewyk F A Wessels, Sabine C Linn, Wayne D Tilley, Anton Simeonov, Simak Ali, Wilbert Zwart
Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer. Cancer research 80 (10) (2020)
Georgina P Sava, Hailing Fan, Rosemary A Fisher, Sabrina Lusvarghi, Sunil Pancholi, Suresh V Ambudkar, Lesley-Ann Martin, R Charles Coombes, Lakjaya Buluwela, Simak Ali
ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942. Oncogene 39 (3) (2019)
Linda Smith, Raed Farzan, Simak Ali, Laki Buluwela, Adrian T Saurin, David W Meek
Author Correction: The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation. Scientific reports 8 (1) (2018)
James W Hindley, Yuval Elani, Catriona M McGilvery, Simak Ali, Charlotte L Bevan, Robert V Law, Oscar Ces
Light-triggered enzymatic reactions in nested vesicle reactors. Nature communications 9 (1) (2018)
Lesley-Ann Martin, Ricardo Ribas, Nikiana Simigdala, Eugene Schuster, Sunil Pancholi, Tencho Tenev, Pascal Gellert, Laki Buluwela, Alison Harrod, Allan Thornhill, Joanna Nikitorowicz-Buniak, Amandeep Bhamra, Marc-Olivier Turgeon, George Poulogiannis, Qiong Gao, Vera Martins, Margaret Hills, Isaac Garcia-Murillas, Charlotte Fribbens, Neill Patani, Zheqi Li, Matthew J Sikora, Nicholas Turner, Wilbert Zwart, Steffi Oesterreich, Jason Carroll, Simak Ali, Mitch Dowsett
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. Nature communications 8 (1) (2017)
Linda Smith, Raed Farzan, Simak Ali, Laki Buluwela, Adrian T Saurin, David W Meek
The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation. Scientific reports 7 (1) (2017)
A Harrod, J Fulton, V T M Nguyen, M Periyasamy, L Ramos-Garcia, C-F Lai, G Metodieva, A de Giorgio, R L Williams, D B Santos, P J Gomez, M-L Lin, M V Metodiev, J Stebbing, Castellano L, Luca Magnani, R C Coombes, L Buluwela, Simak Ali
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer. Oncogene 36 (16) (2016)
Van T M Nguyen, Iros Barozzi, Monica Faronato, Ylenia Lombardo, Jennifer H Steel, Naina Patel, Philippa Darbre, Castellano L, Balázs Győrffy, Laura Woodley, Alba Meira, Darren K Patten, Valentina Vircillo, Manikandan Periyasamy, Simak Ali, Gianmaria Frige, Saverio Minucci, R Charles Coombes, Luca Magnani
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications 6 (2015)

Simak Ali.css-eqlu8i{font-size:small;padding-left:4px;} (S Ali)

Publication Activity (10 Years)

Top Topics

Top Venues

Simak Ali (S Ali)