SMAC mimetics throw a molecular switch to control TH17 responses.
Stephanie K DouganMichael DouganPublished in: Science signaling (2019)
IL-17 produced by TH17 cells plays a central role in numerous protective and pathologic immune responses. In this issue of Science Signaling, Rizk et al. define a molecular switch controlled by the cellular inhibitor of apoptosis proteins that regulates TH17 immunity.