Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa).

Herman Karim SombiéAbel Pegdwendé SorghoJonas Koudougou KologoAbdoul Karim OuattaraSakinata YaméogoAlbert Théophane YonliFlorencia Wendkuuni DjigmaDaméhan TchelougouDogfounianalo SomdaIsabelle Touwendpoulimdé KiendrébéogoProsper BadoBolni Marius NagaloYoussoufou NagabilaEnagnon Tiémoko Herman Donald AdokoPatrice ZabsonréHassanata MillogoJacques Simporé

Published in: BMC medical genetics (2020)

Our results confirm that GSTT1-null genotype is significantly associated with risk of developing essential hypertension in Burkinabe, especially when BMI < 30 Kg/m2, in non-smokers and in alcohol users, and it showed that the double deletion GSTM1-null/GSTT1-null genotypes may influence body lipids repartition.

Keyphrases

blood pressure
body mass index
genome wide
smoking cessation
weight gain
gene expression
fatty acid
alcohol consumption
physical activity
arterial hypertension
genome wide identification