Placentas associated with female neonates from pregnancies complicated by urinary tract infections have higher cAMP content and cytokines expression than males.

Andrea Olmos-OrtízAlberto Olivares-HuertaJanice García-QuirozTeresa ZariñánRoberto ChaviraVerónica Zaga-ClavellinaEuclides AvilaAli HalhaliMarta DurandFernando LarreaLorenza Díaz-Nieto

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)

Our results showed higher cAMP content and defense cytokines expression in placentas associated with female neonates from pregnancies complicated by UTI. The associations between cAMP and bacteriuria/immune markers, together with cAMP's ability to differentially regulate placental antimicrobial peptides expression, suggest a dual modulatory role for cAMP in placental immunity.

Keyphrases

binding protein
urinary tract infection
poor prognosis
protein kinase
preterm birth
low birth weight
gestational age
preterm infants
innate immune