TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling.
Ming-Dian WangHui-Ting LiLi-Xia PengYan MeiLi-Sheng ZhengChang-Zhi LiDong-Fang MengYan-Hong LangLiang XuXing-Si PengZhi-Jie LiuDe-Huan XieLing-Ling GuoMao-Guang MaLiu-Yan DingBi-Jun HuangYun CaoChao-Nan QianPublished in: Cancer gene therapy (2023)
Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast Asia. Metastasis of NPC remains the main cause of death for NPC patients even though the tumor is sensitive to radiotherapy and chemotherapy. Here, we found that the transmembrane protein tetraspanin1 (TSPAN1) potently inhibited the in vitro migration and invasion, as well as, the in vivo metastasis of NPC cells via interacting with the IKBB protein. In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Furthermore, reduced TSPAN1 expression was associated with NPC metastasis and the poor prognosis of NPC patients. These results uncovered the suppressive role of TSPAN1 against NF-kB signaling in NPC cells for preventing NPC metastasis. Its therapeutic value warrants further investigation.
Keyphrases
- poor prognosis
- induced apoptosis
- signaling pathway
- end stage renal disease
- cell cycle arrest
- ejection fraction
- pi k akt
- oxidative stress
- long non coding rna
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- nuclear factor
- locally advanced
- binding protein
- cell death
- endoplasmic reticulum stress
- small molecule
- patient reported outcomes
- protein protein