LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions.
Peng ZhaoYuanzhong XuLu-Lin JiangXuejun FanZhiqiang KuLeike LiXiaoye LiuMi DengHisashi AraseJay-Jiguang ZhuTimothy Y HuangYingjun ZhaoChengcheng ZhangHuaxi XuQingchun TongNingyan ZhangZhiqiang AnPublished in: Molecular neurodegeneration (2022)
This study revealed for the first time the molecular mechanisms of LILRB2-mediated inhibition of TREM2 signaling in microglia and demonstrated a novel approach of enhancing TREM2-mediated microglia functions by blocking LILRB2-ligand interactions. Translationally, a LILRB2 antagonist antibody completely rescued the inhibition of TREM2 signaling by LILRB2, suggesting a novel therapeutic strategy for improving microglial functions.