Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization.
Sujin JuLeejin LimYoung-Jae KiDong-Hyun ChoiHeesang SongPublished in: Particle and fibre toxicology (2022)
PAHs, including oxy-PAHs, in ambient PM may have dual effects that lead to an increase in VSMC migration. One is the generation of oxidative stress followed by MMP upregulation, and the other is actin reorganization that results from the activation of the focal adhesion complex.
Keyphrases
- cell migration
- polycyclic aromatic hydrocarbons
- particulate matter
- smooth muscle
- oxidative stress
- air pollution
- poor prognosis
- cell proliferation
- dna damage
- diabetic rats
- ischemia reperfusion injury
- induced apoptosis
- signaling pathway
- cystic fibrosis
- staphylococcus aureus
- drinking water
- endoplasmic reticulum stress