Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.

Jingting Xu Zhaoxuan Ruan Zhou Guo Liangcai HouGenchun WangZehang ZhengXiong ZhangHaigang LiuKai SunFeng-Jin Guo

Published in: Bone & joint research (2024)

Our results demonstrate that inhibition of Sat1 could alleviate chondrocyte ferroptosis and inflammation by downregulating Alox15 activating the Nrf2 system, and delaying the progression of OA. These findings suggest that Sat1 provides a new approach for studying and treating OA.

Keyphrases

oxidative stress
cell death
signaling pathway
poor prognosis
knee osteoarthritis
mouse model
binding protein