Serum glucose excretion after Roux-en-Y gastric bypass: a potential target for diabetes treatment.
In Gyu KwonChan Woo KangJong Pil ParkJu Hun OhEun Kyung WangTae Young KimJin Sol SungNamhee ParkYang Jong LeeHak-Joon SungEun Jig LeeWoo Jin HyungSu-Jin ShinSung Hoon NohMijin YunWon Jun KangArthur ChoCheol-Ryong KuPublished in: Gut (2020)
Bariatric surgery or AREG administration induces apical and basolateral membrane GLUT1 expression in the small intestinal enterocytes, resulting in increased serum glucose excretion in the gut lumen. Our findings suggest a novel, potentially targetable glucose homeostatic mechanism in the small intestine.