ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion.
Sho IshiiTakeo IsozakiHidekazu FuruyaHiroko TakeuchiYumi TsubokuraKatsunori InagakiTsuyoshi KasamaPublished in: Arthritis research & therapy (2018)
These data indicate that ADAM-17 is expressed on RA STs and plays a role in RA inflammation by regulating monocyte adhesion to RA FLSs. ADAM-17 might be an important inflammatory mediator in inflammatory diseases such as RA.
Keyphrases
- rheumatoid arthritis
- disease activity
- oxidative stress
- ankylosing spondylitis
- interstitial lung disease
- dendritic cells
- systemic lupus erythematosus
- poor prognosis
- endothelial cells
- electronic health record
- cell migration
- immune response
- binding protein
- escherichia coli
- systemic sclerosis
- machine learning
- cell adhesion
- data analysis