Prophylactic acid suppressants in children in the intensive care unit: a systematic review with meta-analysis and trial sequential analysis.

Martine M JensenSøren Marker Hien Quoc Do Marija Barbateskovic Anders Perner Morten Hylander Möller

Published in: Acta anaesthesiologica Scandinavica (2020)

We found no difference in all-cause mortality, overt gastrointestinal bleeding or hospital-acquired pneumonia in children in intensive care receiving acid suppressants compared with placebo/no prophylaxis. However, the quantity and quality of evidence was very low with no firm evidence for benefit or harm.

Keyphrases

young adults
phase iii
clinical trial
healthcare
study protocol
randomized controlled trial
intensive care unit
phase ii
double blind
adverse drug
electronic health record