Login / Signup

Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway.

N N V RadharaniAmit S YadavRamakrishna NimmaT V Santosh KumarAnuradha BulbuleVenkatesh ChanukuppaDhiraj KumarSrinivas PatnaikSrikanth RapoleGopal C Kundu
Published in: Cancer cell international (2022)
These finding provide evidence that TAM derived IL-6 plays a major role in CSC enrichment and tumor progression in breast cancer and IL-6 and its regulated signalling network may act as potential therapeutic target for management of breast cancer.
Keyphrases
  • cancer stem cells
  • poor prognosis
  • adipose tissue
  • cell proliferation
  • transcription factor
  • risk assessment
  • climate change