Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway.
N N V RadharaniAmit S YadavRamakrishna NimmaT V Santosh KumarAnuradha BulbuleVenkatesh ChanukuppaDhiraj KumarSrinivas PatnaikSrikanth RapoleGopal C KunduPublished in: Cancer cell international (2022)
These finding provide evidence that TAM derived IL-6 plays a major role in CSC enrichment and tumor progression in breast cancer and IL-6 and its regulated signalling network may act as potential therapeutic target for management of breast cancer.