Trop-2 and Nectin-4 immunohistochemical expression in metastatic colorectal cancer: searching for the right population for drugs' development.
Roberto MorettoMarco Maria GermaniMirella GiordanoVeronica ConcaAgnese ProiettiCristina NiccoliFilippo PietrantonioSara LonardiEmiliano TamburiniAlberto ZaniboniAlessandro PassardiTiziana Pia LatianoValentina FanottoSamantha Di DonatoMichele PrisciandaroFrancesca BergamoGianluca MasiGabriella FontaniniClara UgoliniChiara CremoliniPublished in: British journal of cancer (2023)
In mCRC, expression levels of Trop-2 and Nectin-4 are heterogeneous, suggesting a target-driven development of anti-Trop2 and anti-Nectin-4 ADCs. Medium/high Trop-2 expression is associated with worse prognosis and higher benefit from chemotherapy intensification.