Transcriptomic analyses of murine ventricular cardiomyocytes.
Morgan ChevalierSarah H VermijKurt WylerLudovic GilletIrene KellerHugues AbrielPublished in: Scientific data (2018)
Mice are used universally as model organisms for studying heart physiology, and a plethora of genetically modified mouse models exist to study cardiac disease. Transcriptomic data for whole-heart tissue are available, but not yet for isolated ventricular cardiomyocytes. Our lab therefore collected comprehensive RNA-seq data from wildtype murine ventricular cardiomyocytes as well as from knockout models of the ion channel regulators CASK, dystrophin, and SAP97. We also elucidate ion channel expression from wild-type cells to help forward the debate about which ion channels are expressed in cardiomyocytes. Researchers studying the heart, and especially cardiac arrhythmias, may benefit from these cardiomyocyte-specific transcriptomic data to assess expression of genes of interest.
Keyphrases
- rna seq
- single cell
- heart failure
- left ventricular
- wild type
- electronic health record
- poor prognosis
- high glucose
- big data
- atrial fibrillation
- catheter ablation
- induced apoptosis
- mouse model
- binding protein
- cell cycle arrest
- duchenne muscular dystrophy
- gene expression
- data analysis
- cell death
- long non coding rna
- skeletal muscle
- endothelial cells
- oxidative stress
- dna methylation
- gram negative
- high fat diet induced
- congenital heart disease