Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study.
Sarah L N ClarkeHannah J JonesGemma C SharpKayleigh E EaseyAlun D HughesAthimalaipet V RamananCaroline L ReltonPublished in: Pediatric rheumatology online journal (2022)
Genetic liability to JIA is associated with multiple cardiovascular risk factors, supporting the hypothesis of increased cardiovascular risk in JIA. Our findings suggest that cardiovascular risk is a core feature of JIA, rather than secondary to the disease activity/treatment, and that cardiovascular risk counselling should form part of patient care.
Keyphrases
- juvenile idiopathic arthritis
- disease activity
- cardiovascular risk factors
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- cardiovascular disease
- metabolic syndrome
- machine learning
- deep learning
- depressive symptoms
- genome wide
- type diabetes
- dna methylation
- copy number
- hepatitis c virus
- replacement therapy