Use of dornase alfa in the paediatric intensive care unit: current literature and a national cross-sectional survey.

Bibiche den HollanderRosalie S N LinssenBart CortjensFardi S van Etten-JamaludinJob B M van WoenselReinout A Bemnull null

Published in: European journal of hospital pharmacy : science and practice (2020)

The off-label use of dornase alfa in the PICU is frequent without strong evidence or local protocols, highlighting the need for further research on the effectiveness of this mucolytic agent.

Keyphrases

intensive care unit
systematic review
replacement therapy
randomized controlled trial
mechanical ventilation
quality improvement
emergency department
smoking cessation
acute respiratory distress syndrome