Down-regulation of metabolic pathways could offset the poor prognosis conferred by co-existent diabetes mellitus in pancreatic (head) adenocarcinoma.
Nilesh GardiMadhura KetkarRoss A McKinnonStephen J PandolShilpee DuttSavio George BarretoPublished in: ANZ journal of surgery (2021)
A significant proportion of patients with PDAC of pancreatic head and DM exhibit downregulation of pathways involved in cellular metabolism, hormone secretion and signalling accompanied by a paucity of islet expression. Investigating the relationship between DM and gene expression profiles in patients with PDAC presents opportunities to improve overall survival in diabetics with PDAC.
Keyphrases
- poor prognosis
- glycemic control
- long non coding rna
- optic nerve
- type diabetes
- squamous cell carcinoma
- cell proliferation
- copy number
- signaling pathway
- genome wide
- locally advanced
- weight loss
- free survival
- radiation therapy
- adipose tissue
- genome wide identification
- skeletal muscle
- transcription factor
- genome wide analysis